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Christensen AO, Li G, Young CH, Snow B, Khan SA, DeVore SB, Edwards S, Bouma GJ, Navratil AM, Cherrington BD *, Rothfuss HM. Peptidylarginine deiminase (PAD) enzymes and Citrullinated proteins in female reproductive physiology and associated diseases. Biol Reprod. 2022 Sep 10:ioac173. doi: 10.1093/biolre/ioac173. Epub ahead of print. PMID: 36087287. * Corresponding author. 

Okamoto Y, Devoe S, Seto N, Minarchick V, Wilson T, Rothfuss HM, Mohning MP, Arbet J, Kroehl M, Visser A, August J, Thomas SM, Charry LL, Fleischer C, Feser ML, Frazer-Abel AA, Norris JM, Cherrington BD, Janssen WJ, Kaplan MJ, Deane KD, Holers VM, Demoruelle MK. Association of Sputum Neutrophil Extracellular Trap Subsets With IgA Anti-Citrullinated Protein Antibodies in Subjects at Risk for Rheumatoid Arthritis. Arthritis Rheumatol. 2022 Jan;74(1):38-48. doi: 10.1002/art.41948. Epub 2021 Nov 25. PMID: 34369110; PMCID: PMC8712364. 

Young CH, Snow B, DeVore SB, Mohandass A, Nemmara VV, Thompson PR, Thyagarajan B, Navratil AM, Cherrington BD. Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells. Reproduction. 2021 Jul 8;162(2):117-127. doi: 10.1530/REP-21-0132. PMID: 34034233; PMCID: PMC8284904. 

Clay CM, Cherrington BD, Navratil AM. Plasticity of Anterior Pituitary Gonadotrope Cells Facilitates the Pre-Ovulatory LH Surge. Front Endocrinol (Lausanne). 2021 Feb 4;11:616053. doi: 10.3389/fendo.2020.616053. PMID: 33613451; PMCID: PMC7890248. 

Li G, Young CH, Snow B, Christensen AO, Demoruelle MK, Nemmara VV, Thompson PR, Rothfuss HM, Cherrington BD. Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome. Int J Mol Sci. 2020 Apr 10;21(7):2634. doi: 10.3390/ijms21072634. PMID: 32290104; PMCID: PMC7177251. 

Zhang X, Xiao H, Zhang X, E Q, Gong X, Li T, Han Y, Ying X, Cherrington BD, Xu B, Liu X, Zhang X. Decreased microRNA-125b-5p disrupts follicle steroidogenesis through targeting PAK3/ERK1/2 signalling in mouse preantral follicles. Metabolism. 2020 Jun;107:154241. doi: 10.1016/j.metabol.2020.154241. Epub 2020 Apr 15. PMID: 32304754. 

Devore SB, Young CH, Li G, Sundararajan A, Ramaraj T, Mudge J, Schilkey F, Muth A, Thompson PR, Cherrington BD.  Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells. Mol Cell Biol. 2018. Jul 9. pii: MCB.00084-18. doi: 10.1128/MCB.00084-18. PMID: 29987187. Selected as a Spotlight Article of significant interest in the September 2018 issue of MCB.  

Acevedo-Rodriguez A, Kauffman AS, Cherrington BD, Laconi M, Borges CS, Roepke TA, Laconi M. Emerging insights into Hypothalamic-pituitary-gonadal (HPG) axis regulation and interaction with stress signaling. J Neuroendocrinol. 2018 Oct;30(10):e12590. doi: 10.1111/jne.12590.  PMID: 29524268. 

Firkus T, Rahel FJ, Bergman HL, Cherrington BD. Warmed Winter Water Temperatures Alter Reproduction in Two Fish Species. Environ Manage. 2018 Feb;61(2):291-303. doi: 10.1007/s00267-017-0954-9. PMID: 29124337. 

Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, Mahler M, Norris JM, Kaplan MJ, Cherrington BD, Holers VM, Deane KD. Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2017 Jun;69(6):1165-1175. doi: 10.1002/art.40066. PMID: 28182854.  

Young CH, Rothfuss HM, Gard PF, Muth A, Thompson PR, Ashley RL, Cherrington BD.  Citrullination regulates the expression of insulin like growth factor binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells.  Reproduction. 2017 Jan;153(1):1-10. doi: 10.1530/REP-16-0494. PMID: 29565015. 

Khan SA, Edwards BS, Muth A, Thompson PR, Cherrington BD*, Navratil AM. GnRH stimulates peptidylarginine deiminase catalyzed histone citrullination in gonadotrope cells. Mol Endocrinol. 2016 Oct;30(10):1081-1091. PMID: 27603413. Website featured article. *Equal contribution as Corresponding Author. 

Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD. Peptidylarginine deiminase 3 (PAD3) is upregulated by prolactin stimulation of CID-9 cells and expressed in the lactating mouse mammary gland. PLoS One. 2016 Jan 22;11(1):e0147503. doi: 10.1371/journal.pone.0147503. PMID: 26799659. 

Edwards BS, Dang AK, Murtazina DA, Dozier MG, Whitesell JD, Khan SA, Cherrington BD, Amberg GC, Clay CM, Navratil AM.  Dynamin is required for GnRH signaling to L-type calcium channels and activation of ERK. Endocrinology. 2016 Feb;157(2):831-43. doi: 10.1210/en.2015-1575. PMID: 26696122. Selected for journal cover image.  

Stadler SC, Vincent CT, Patsialou A, Cherrington BD, Fedorov VD, Wakshlag JJ, Mohanan S, Zee BM, Zhang X, Condeelis J, Garcia BA, Brown AMC, Coonrod SA, Allis CD.  Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.  Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11851-6. doi: 10.1073/pnas.1308362110. PMID: 23818587. 

Xie H, Cherrington BD, Mellon PL. Msx1 homeodomain protein represses the α-GSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar;27(3):422-36. doi: 10.1210/me.2012-1289. PMID: 23371388 

McElwee JL, Mohanan S, Griffith OL, Cherrington BD, Anguish LJ, Breuer HC, Thompson PR, Gray JW, Coonrod SA.  Identification of PAD2 as a potential breast cancer biomarker and therapeutic target.  BMC Cancer. 2012 Oct 30;12:500. doi: 10.1186/1471-2407-12-500.  PMID: 23110523. 

Mohanan S, Cherrington BD, Horibata S, McElwee JL, Thompson PR and Coonrod SA. Potential role of peptidylarginine deiminase enzymes (PADs) and protein citrullination in cancer pathogenesis. Biochem Res Int. 2012;2012:895343.  PMID: 23019525. 

Cherrington BD, Zhang X, McElwee JL, Morency E, Anguish LJ, Coonrod SA. Potential role for PAD2 in gene regulation in breast cancer cells. PLoS One. 2012;7(7):e41242. doi: 10.1371/journal.pone.0041242. PMID: 22911765. 

Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13331-6. doi: 10.1073/pnas.1203280109. PMID: 22853951. 

Horibata S, Coonrod SA, Cherrington BD. Role for peptidylarginine deiminase (PAD) proteins in disease and female reproduction.  J Reprod Dev. 2012;58(3):274-82. Review. PMID: 22790870. 

Cherrington BD, Mohanan S, Diep AN, Fleiss R, Buckles EL, Anguish LJ, Coonrod SA, Wakshlag JJ. Comparative analysis of peptidylarginine deiminase 2 (PAD2) expression in canine, feline, and human mammary tumors. J Comp Pathol. 2012 Aug-Oct;147(2-3):139-46. doi: 10.1016/j.jcpa.2012.01.021. PMID: 21655091. 

Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Allis CD, Kraus WL, Coonrod SA. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-fos expression in breast cancer cells.  PLoS Genet. 2011 Jun;7(6):e1002112. doi: 10.1371/journal.pgen.1002112. PMID: 21655091. 

Cherrington BD, Morency E, Struble AM, Coonrod SA, Wakshlag JJ. Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. PLoS One. PLoS One. 2010 Jul 26;5(7):e11768. doi: 10.1371/journal.pone.0011768. PMID: 20668670. 

Navratil AM, Song H, Hernandez JB, Cherrington BD, Santos SJ, Low JM, Do MH, Lawson MA. Insulin augments gonadotropin-releasing hormone induction of translation in Lbeta T2 cells. Mol Cell Endocrinol. 2009 Nov 13;311(1-2):47-54. doi: 10.1016/j.mce.2009.07.014. PMID: 19632296. 

Lents CA, Farmerie TA, Cherrington BD, Clay CM. Transcriptional activity of the murine gonadotropin-releasing hormone receptor gene promoter is regulated by Oct-1 acting at core homeodomain DNA-binding sites at various locations.  Endocrine. 2009 Jun;35(3):356-64. doi: 10.1007/s12020-009-9167-1. PMID: 19333792. 

Cherrington BD, Bailey JS, Diaz AL, Mellon PL. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 2008 Nov 25;295(1-2):106-14. doi: 10.1016/j.mce.2008.07.017. PMID: 18760324.  

Albertson AJ, Navratil A, Mignot M, Dufourny L, Cherrington B, Skinner DC.  Immunoreactive GnRH type I receptors in the mouse and sheep brain. J Chem Neuroanat. 2008 Jul;35(4):326-33. doi: 10.1016/j.jchemneu.2008.03.004. PMID: 18439800.  

Cherrington BD, Farmerie TA, Clay CM.  A specific helical orientation underlies the functional contribution of the activin responsive unit to transcriptional activity of the murine gonadotropin releasing hormone receptor gene promoter.  Endocrine. 2006 Jun;29(3):425-33. PMID: 16943581.  

Cherrington BD, Farmerie TA, Lents CA, Cantlon JD, Roberson MS, Clay CM.  Activin responsiveness of the murine gonadotropin-releasing hormone receptor gene is mediated by a composite enhancer containing spatially distinct regulatory elements. Mol Endocrinol. 2005 Apr;19(4):898-912. PMID: 15637149. 

Ellsworth BS, White BR, Burns AT, Cherrington BD, Otis AM, Clay CM. c-Jun N-terminal kinase activation of activator protein-1 underlies homologous regulation of the gonadotropin-releasing hormone receptor gene in alpha T3-1 cells. Endocrinology. 2003 Mar;144(3):839-49. PMID: 12586760. 

Book Chapter 

Cherrington BD*, Mohanan S, Coonrod SA. 2013. Ch. 17, “PAD Enzymes in Female Reproductive Tissues and Cancer Pathogenesis”. In: Protein Deimination in Human Health and Disease, S. Bhattacharya and A. Nicholas (eds.) DOI 10.1007/987-1-4614-8317-5_17, Springer Science+Business Media New York 2013. * Corresponding author.